Harm Reduction Therapeutics

We See You

Through the Eyes ofRiVive

We See You

Through the Eyes ofRiVive

We See You

Through the Eyes ofRiVive

We See You

Through the Eyes ofRiVive

We See You

Through the Eyes ofRiVive

We See You

Through the Eyes ofRiVive

If you are a first-time drug user, we see you. If you are someone who uses drugs regularly, we see you. If you are a concerned parent, the child of a parent who uses, a friend, EMS, supporting a harm reduction program, or just concerned about people in your community,

WE SEE ALL OF YOU.

We understand substance use is multilayered and that it comes with inherent risk. Our goal for RiVive is for you to stay alive.

Harm Reduction Therapeutics

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In moments of crisis

compassion RiVives®.

RiVive Naloxone HCL Nasal Spray 3 mg
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RiVive (R)

RiVive Naloxone HCI Nasal Spray 3 mg is an FDA-approved over-the-counter (OTC) compassionate dose naloxone product. It’s intended for the emergency treatment of opioid overdose and is manufactured right here in the United States. According to the CDC, naloxone is a safe and effective life-saving medication that can reverse an opioid overdose—including heroin and fentanyl.

RiVive is strong enough to save lives with the lowest dose of OTC intranasal naloxone available in the U.S., and it reduces the risk of precipitated withdrawal. RiVive offers Compassionate Overdose ResponseTM intended to rescue and not punish the person experiencing an overdose. Competitive products are formulated with higher doses of naloxone which can increase the risks of precipitated withdrawal symptoms caused from using more naloxone than may be necessary to reverse an overdose, including vomiting, anxiety, nausea, disorientation, irritability, especially for those with opioid dependence.

Harm Reduction Therapeutics, Inc. (HRT) is able to sell RiVive at a low price thanks to our status as the only 501(c)(3) non-profit pharmaceutical company that manufactures naloxone. Our manufacturing cost is our price, we make zero profit on RiVive.

“This allows us to SAVE AS MANY LIVES AS POSSIBLE THAT WOULD OTHERWISE BE LOST TO OPIOID OVERDOSE.”

-Michael R. Hufford, PhD
 Co-Founder & CEO
Made in U.S.A., Manufactured in North Carolina, Packaged in Indiana

How to Administer

Learn how you can save lives with RiVive in 5 easy steps by watching this video.
Please only use as directed.

RiVive: 5 Key Steps in Case of an Overdose
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Warning: when using this product, some people may experience symptoms when they wake up such as shaking, sweating, nausea, or feeling irritable.

Our Mission

At Harm Reduction Therapeutics, our mission is rooted in compassion. We believe in a world where every life is valued, and where help is within reach for those facing the threat of overdose. With a deep sense of empathy and commitment, we developed RiVive, an OTC naloxone nasal spray to provide life-saving support when it’s needed most. Guided by the understanding that behind every statistic is a person, we bring accessible, compassionate care. Together we can help each other stay alive with RiVive.

Michael R. Hufford, PhD
Co-Founder & Chief Executive Officer

Learn More

“We are so excited to be able to offer a compassionate dose of nasal naloxone to people who are at risk of overdose and reversing overdoses daily. A program participant recently asked, 'Why does Pennsylvania not already have 3 mg naloxone available?' Nobody ever asks us for what we need or pays attention when we say it. We're tired of being forced to make our friends so sick to bring them back, so we are very happy to be able to have RiVive to offer them now!”

-Alice Bell, Overdose Prevention Project Director – Prevention Point Pittsburgh, and harm reduction pioneer

“RiVive is definitely a far superior product than any naloxone I've ever used. It works well, efficiently, and nobody I've used it on feels sick after. It's so much nicer, I mean it works."

-N.F., friend who administered RiVive, Kewanee, IL

"I could definitely tell the difference between the RiVive and Narcan, which made my friend sick. When I used the RiVive, it definitely worked a lot better. It's made more for the people who use and less for the people around them."

-M.C., friend who administered RiVive, Kewanee, IL

“At this time, and in alignment with other experts from across the U.S., we do not recommend the use of any high-dose or long-acting overdose reversal agents in Pennsylvania by community groups, treatment providers, EMS and other first responders, or bystanders with access to naloxone. We also support the Call to Action emerging from the national Compassionate Overdose Response Summit."

–Expert Statement Regarding High-Dose Naloxone and Long-Acting Opioid Overdose Reversal Formulations in Pennsylvania, August 19, 2025

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Proven to
Save Lives

  1. Avetian, et al. (2018) DOI: 10.1080/03007995.2017.1334637.
  2. Wheeler, E., et al., Opioid Overdose Prevention Programs Providing Naloxone to Laypersons, 2014.
  3. McClellan, C., et al., Opioid-overdose laws association with opioid use and overdose mortality. Addictive Behaviors, 2018. 86: p. 90-95.
  4. Townsend, T., et al., Cost-effectiveness analysis of alternative naloxone distribution strategies: First responder and lay distribution in the United States. International Journal of Drug Policy, 2019.
  • Naloxone has been shown to be successful in reversing overdoses in 98.8% of cases.1
  • The CDC reports that tens of thousands of lives have been saved since 1996.2
  • A national study showed overdose deaths decreased by 14% in states that enacted naloxone access laws.3
  • Statistical modeling indicates that greater naloxone availability could reduce overdose deaths by 21%.4